An ACTH-secreting pituitary adenoma within the sphenoid sinus.
نویسندگان
چکیده
A 68-year-old woman developed Cushingoid features three months prior to admission. She was found to have a markedly elevated plasma ACTH-cortisol level. Magnetic resonance imaging (MRI) revealed a mass in the left sphenoidal sinus, which had become enlarged to a point where it could not be removed by transsphenoidal surgery. We decided to proceed with radiation therapy to shrink the tumor. However, it was ineffective. Despite a reduction in serum cortisol levels using metyrapone, she died of septic shock. We describe a rare case of an ACTH-secreting pituitary adenoma within the sphenoid sinus.
منابع مشابه
Acromegaly in a patient with normal pituitary gland and somatotropic adenoma located in the sphenoid sinus Akromegalia u chorego z prawidłową przysadką i gruczolakiem somatotropowym położonym w zatoce klinowej
Ectopic acromegaly is a very rare clinical entity occurring in less than 1% of acromegalic patients. In most cases it is caused by GHRH or rarely GH–secreting neoplasms. Even rarer are ectopic pituitary adenomas located in the sphenoid sinus or nasopharynx that originate from pituitary remnants in the craniopharyngeal duct. This dissertation presents the difficulties in visualizing GH-secreting...
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INTRODUCTION Ectopic pituitary adenoma is defined as adenoma that occurs outside the sella without any continuity with the normal pituitary gland [1]. Since its description for the first time in 1909 by Erdheim in the vomero-sphenoidal region, about 75 cases have been reported in literature [2-12]. Sphenoid sinus followed by the suprasellar region remains the most common site for these adenomas...
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BACKGROUND The diagnosis of Cushing disease is based on endocrinological pa-rameters, with no single test being specific. In some patients, dynamic thin-slice sellar magnetic resonance imaging fails to detect a pituitary tumor. OBJECTIVE The purpose of this study is to investigate the role of ectopic pituitary adenoma in this situation. METHODS In a retrospective chart review, 5 patients (6...
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Pituitary adenomas are benign, slow-growing tumors, which account for 15% of all intracranial tumors in adults. Ectopic pituitary adenoma (EPA) is a rare presentation first described by Erdheim in 1909. Most of the EPAs described in literature occur in the suprasellar region or the sphenoid sinus. We describe a case of an EPA originating from the choana presenting as a case of nasal mass along ...
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Routine classification of pituitary adenomas is not appropriate for diagnosis of adenoma type and in some cases there is inconcordance between clinical presentation and histological type of adenoma. The aim of this study was to determine the type of adenoma secretion based on immunohistochemical staining. 102 paraffin blocked specimens of pituitary adenoma were stained with hormone ...
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ورودعنوان ژورنال:
- Internal medicine
دوره 49 8 شماره
صفحات -
تاریخ انتشار 2010